Biomedical Physics: NMR, MRI
The long-standing research tradition of the Department in the field
of Nuclear Magnetic Resonance, more recently in magnetic resonance imaging and SQUID
magneto-encephalography, is at the basis of fruitful collaborations with IRCCS and hospitals
on various themes. The main research directions are:
(a) Novel multifunctional magnetic nanoparticles and paramagnetic molecules, which can be used both as contrast agents for the medical diagnostics (MRI and/or optical) and for the therapy (either through the hyperthermia or drug delivery), are being developed and investigated. Similar studies are performed on magnetosomes which are naturally present in magnetotactic bacteria. The employment of the magnetic nanoparticles as biosensors is also investigated. Such research activities are carried out in collaboration with Colorobbia Italia, with Fondazione Mondino, with the European Oncology Institute, and with the Carlo Besta Neurological Institute.
(b) A new technique for the hyperpolarization of nuclear magnetic moments in molecules involved in the metabolism is being developed. The goal is to visualize such molecules and their conversion into other molecules involved in the metabolism through magnetic resonance imaging techniques, and thus to be able to diagnose the presence of possible pathologies at an early stage. This activity is performed in collaboration with Bracco Imaging S.p.A. Furthermore, thanks to nuclear magnetic resonance measurements, it is possible to estimate the spatial distribution and quantity of Boron nuclei, which are injected in tissues, and to distinguish between regions with and without tumors. Such technique is connected to the tumor therapy employing neutron capture (BNCT).
Staff: P. Carretta, M. Corti, A. Lascialfari, M. Moscardini