Work Package 6 - CAPTURE-ENHANCED NEUTRON IRRADIATION (CENI) EFFECTIVENESS

Lead beneficiary: Mario Negri Institute for Pharmacological Research IRCCS, IRFMN
Involved partners: UNIPV, UNITO, Raylab, SU, UKESSEN
Objectives:
1. to test the therapeutic efficacy of CENI-mediated Gd/B treatment to restore memory in the APP/PS1 AD mice at both pre- and post-symptomatic stages;
2. to test the therapeutic efficacy of Gd/B to reduce the extent of neuropathology at the level of multiple neuropathological targets in APP/PS1 AD mice at both pre- and post-symptomatic stages.